Our group has shown that GRK2 impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia in an animal model, confirming that GRK2 could be an important hub in the regulation of cardiac function and metabolism during cardiac stress (Ciccarelli et al., 2011; Woodall et al., 2014; Mayor et al., 2018). The gene discussed is GRK2; the disease is myocardial ischemia.