The Ddit3 and Hspa5 results are especially intriguing as depletion of DDIT3 has been shown to exacerbate disease in PMD animal models (Southwood et al., 2002), while reduction of HSPA5 is deleterious to oligodendrocyte survival in both normal and autoimmune disease contexts (Hussien et al., 2015) and is depleted in PMD models (Numata et al., 2013). Here, HSPA5 is linked to Pelizeaus-Merzbacher spectrum disorder.