In their review illustrating immune dysregulation and inflammation response (Chen et al. 2016) Chen et al. identified several potential PD biomarkers: immunological genes (such as some human leukocyte antigen genes), PD-related genes (directly influencing α-synuclein accumulation), PD-related microRNAs (which modulate PD genes at a post-transcriptional level), specific antibodies (such as elongation factor 1-alpha-1 and poly (A) binding protein cytoplasmic-3), inflammatory factors (such as cytokines). The gene discussed is SNCA; the disease is Parkinson disease.