In addition, the clinicopathological and prognostic value of PD-L1 has been investigated in some recent studies and meta-analyses, in which several clinicopathological prognostic factors of renal tumors, such as the WHO/ISUP grade, presence of necrosis, tumor size, TNM stage have been compared with the PD-L1 expression, and a considerable correlation between some of these factors has been determined. The gene discussed is CD274; the disease is neoplasm.