Our study showed a strong association of increased levels of the HIF-2α expression in PD-L1-positive ccRCC tumor samples by immunohistochemistry, demonstrating the correlation between the increased PD-L1 and HIF expression, suggesting that the regulation of PD-L1 might depend on the HIF expression [5, 8]. Here, EPAS1 is linked to nonpapillary renal cell carcinoma.