We examined the association of both TLR3 SNPs with the disease stages of chronic HBV infection, specified through the following analyses: 1) HBV DNA levels, 2) ALT levels; 3) the IC state vs. non-IC state; 4) HBeAg-negative vs. HBeAg-positive CHB; and the presence or absence of 5) cirrhosis and 6) HCC across the CHB cohort. Here, TLR3 is linked to hepatocellular carcinoma.