In our cross sectional study of elderly subjects we observed increased IL-1α, IL-1Ra, IL-4, IL-6, IL-8, IL-17, TNF-α, IP-10, RANTES, CD40L and VEGF levels already in the individuals with prediabetes, while MCP-1, active PAI-1, MPO, E-selectin, VCAM-1, ICAM-1 and DPPIV were unchanged, and adiponectin levels decreased. This evidence concerns the gene CD40LG and prediabetes syndrome.