S100A8 and infection: In addition to these, to establish what are common factors among Chinese and India population, a comparative analysis is required to establish common pre-disposing and risk factors (achalasia, atrophic gastritis83, an infection by cytotoxin-associated gene A (CagA)-positive Helicobacter pylori84, injury to the esophagus, consumption of pickled vegetables, Plummer Vinson syndrome, Chaggas-associated mega-esophagus, and a history of certain head and neck cancers)85.