An overexpression of MMP2 has been reported in ESCC tissues as compared to adjacent normal epithelia52, and MMP3 SNP (MMP3 -1612 5A/6A) polymorphism was significantly associated with susceptibility to ESCC means ESCC subjects bearing 5A allele were more prone of getting ESCC as compared with 6A allele50. Here, MMP2 is linked to esophageal squamous cell carcinoma.