Consistently, the tumor tissues in TRIM27-deficient mice had decreased STAT3 activation, lower levels of inflammatory cytokines, lower infiltration of inflammatory cells, and decreased induction of STAT3 target genes including Bcl-xl, c-Myc, Pcna, and Ccnd1. These results suggest that TRIM27 plays important roles in CAC development. The gene discussed is PCNA; the disease is neoplasm.