Moreover, there was also a decrease in levels of inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-17A in the sera or colon tissues of Trim27−/− mice (Fig. 8e), which was consistent with the decreased inflammatory cell infiltrations in colon tumors of Trim27−/− mice (Fig. 8c). Here, IL6 is linked to colonic neoplasm.