STAT3 and colitis: As expected, TRIM27-deficient mice transplanted with hematopoietic cells from TRIM27-deficient mice (KO > KO) were less susceptible to DSS-induced colitis than wild-type mice receiving hematopoietic cells from wild-type mice (WT > WT) as determined by less body weight loss, higher survival rate, reduced colon shortening, less inflammatory cells infiltration, lower histological score, decreased level of phosphorylated STAT3, and p65 and lower expression of inflammatory cytokines (Fig. 7a–h).