TRIM27 and neoplasm: Overexpression of TRIM27 markedly promoted anchorage-independent growth of RKO, HEK293, and HeLa cells (Fig. 5a and Supplementary Figure 5a, b) in vitro and tumor growth in nude mice (Fig. 5b and Supplementary Figure 5c), whereas knockdown of TRIM27 had opposite effects (Fig. 5c, d and Supplementary Figure 5d, e, f).