TRIM27 and colitis: Histopathological analysis revealed that the colonic mucosa of Trim27−/− mice was more intact without apparent loss of crypt structures and mucosal ulceration and the colonic tissues of Trim27−/− mice had less infiltration of inflammatory cells in comparison to that of their wild-type littermates after DSS treatment (Fig. 6d), which was also reflected in the pathological assessment of colitis severity scores (Fig. 6e).