EGFR and hepatocellular carcinoma: In contrast, when the HCC cells were incubated with scAb-EGFR-PEG-g-PEI-SPION/PBOV1-psiRNA1 and scAb-EGFR-PEG-g-PEI-SPION/PBOV1-psiRNA2 (TS1 and TS2 groups), the growth and metastasis significantly decreased, following the downregulation of PBOV1 gene expression.