In comparison with that in normal human hepatic cell lines (L02 and HHL-5), the EGFR expression levels were markedly upregulated in multiple HCC cell membranes, including Hep3B, BEL7402, SNU423, SMMC-7721, PLC/PRF/5, Huh7, HLE, HLF, HepG2.2.1, SK-Hep1, and HepG2 (Fig. 1e, Supplementary Fig. 1b). Here, EGFR is linked to hepatocellular carcinoma.