As NMDAR hypomorph mice show up to 95% reduced expression of GluN122,50, a reduction much greater than what has been shown in postmortem studies of schizophrenia brains65,66, heterozygous GluN1−/− mice exhibiting a 30% reduced expression of GluN1 have been proposed to be more disease relevant in schizophrenia studies50. This evidence concerns the gene GRIN1 and schizophrenia.