Of those studies, one study included APOE in the GRS and reported a 3.34 fold increased risk of AD in individuals in the 10th decile of the GRS compared to the 1st decile 15 and the remaining four studies did not include APOE in the GRS with HR range: 1.11 (per SD) – 2.36 (84–16 percentile)19,29–31. Here, APOE is linked to Alzheimer disease.