Curiously, while Gprc5a constitutive knockout mice (Gprc5a−/−) are reported to have a higher prevalence of spontaneous late‐onset lung tumours than their wild‐type littermates (Tao et al, 2007; Kadara et al, 2010), a recent report showed that the same Gprc5a−/− mice are actually resistant to inflammation‐induced intestinal tumorigenesis, with dramatic reductions intestinal tumours ≥ 3 mm (Zhang et al, 2017). This evidence concerns the gene GPRC5A and intestinal neoplasm.