GPRC5A and neoplasm: Based on our mechanistic findings, we speculate that without GPRC5A, such tumours would be compromised in their ability to grow due to a failure to engage the HIF‐GPRC5A‐YAP axis, thereby unable to survive hypoxic stress. This is further supported by emerging evidence that indicates pro‐survival roles for YAP in oxygen‐regulated processes in a variety of contexts (Ma et al, 2015; Santinon et al, 2016; Wang et al, 2017).