In previous study, we reported that odontogenic ameloblast-associated protein (ODAM) was extruded from the JE following the onset of JE attachment loss and was detected in gingival crevicular fluid (GCF), and proposed that ODAM could be used as a biomarker of periodontitis and peri-implantitis [5]. The gene discussed is ODAM; the disease is Peri-Implantitis.