AFF1 and Ataxia: Two types of transcription factors found in 75% of eukaryotic species listed in the comparative genomics resource PhyloPro v2 [53] were not predicted in S. mediterranea: AF-4 (a transcriptional activator that has previously been implicated in childhood lymphoblastic leukemia, mental retardation, and ataxia [56]) and Myc_N (a leucine zipper-type transcription factor implicated in cell cycle progression, cell death, and transformation).