Based on our survey in Chinese population, the eighteen genes, containing CRYAA, CRYAB, CRYBA1, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGC, CRYGD, CRYGS, GJA8, GJA3, HSF4, MIP, BFSP2, EPHA2, FYCO1 and PITX3, can be chosen as the candidate genes to screen congenital cataracts. The gene discussed is PITX3; the disease is Developmental cataract.