TUBB3 and Familial prostate cancer: The expression profile array (Fig. 3a) showed upregulation of genes in HT-29/EGFP/FUR cells which for example were shown to play part in migration, invasion and correlated with aggressive prostate cancer features - par-6 family cell polarity regulator alpha, PARD6A [28]; were proven to be unfavorable prognostic marker – Cyclin D1, CCND1 [29]; were a cellular survival factor and biomarker of poor outcome – Tubulin Beta 3 Class III, TUBB3 [30]; were a putative tumor promoter – Cyclin D2, CCND2 [31].