In the pathogenesis of Diffuse large B-cell lymphoma (DLBCL), BCL6 transcriptional repressor is the most frequently involved oncoprotein, which is required to sustain proliferation and survival of DLBCL cells through regulation of specific targets such as PRDM1, c-Myc or PAX-5 [13]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.