Since WTAP – via its association with the METTL3/14 heterodimer – impacts on RNA stability [23], we hypothesize that in malignant DLBCL cells abundant WTAP protects WTAP mRNA from degradation, while this positive feedback loop can be interrupted by Hsp90-directed drugs and successive WTAP ubiquitination and proteasomal degradation. Here, WTAP is linked to diffuse large B-cell lymphoma.