Curcumin (C21H20O6, ID IUPAC: (1E, 6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, molar mass: 368.38 g/mol) (Figure 8), another known insulin-sensitizing agent extracted from Curcuma longa, has been associated in numerous preclinical studies and in recent preliminary clinical trials with a significant improvement in NAFLD-related parameters [70]. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.