For example, the pathogenesis of activated B cell-like Diffuse large B-cell lymphoma (ABC DLBCL) involves oncogenic activation of various upstream NF-κB pathway components, including the CD79B subunit of the BCR, CARD11 and MyD88, which drive cancer cell proliferation/survival through canonical NF-κB activity [171,173]. This evidence concerns the gene NFKB1 and cancer.