For example, dual siRNA-mediated knockdown of IKKα and IKKβ or dual IKKα/β inhibition had a greater suppressive effect on canonical NF-κB activation and proliferation, survival and migration of head and neck squamous cell carcinoma (HNSCC) cells than knockdown or inhibition of each IKK individually [134]. The gene discussed is CHUK; the disease is head and neck squamous cell carcinoma.