However, several studies have surprisingly shown that IKKβ inhibition in certain cells/tissues triggers the spontaneous development of severe inflammatory conditions, and in some cases promotes malignant development, indicating anti-inflammatory and tumour suppressor roles for NF-κB; it appears, therefore, that the consequence of IKKβ deletion and NF-κB inhibition is highly cell-type and context dependent [158]. The gene discussed is NFKB1; the disease is neoplasm.