While vismodegib monotherapy does not increase γH2AX/53BP1 nuclear foci in non-irradiated BCC-1 or SCC-25 cells, a combination of vismodegib and 4 Gy-irradiation significantly enhanced the number of persisting (24 h) foci in a concentration-dependent manner (Figure 4). This evidence concerns the gene TP53BP1 and skin basal cell carcinoma.