Moreover, preclinical and clinical data indicate that an aberrant Hh signaling [16,17], mutations in PTCH1 and SMO and overexpression of components of the Hh pathway all correlate with poor clinical outcome in gastric [18], esophageal cancer [19] and in head and neck SCC (HNSCC) [20,21]. Here, PTCH1 is linked to head and neck squamous cell carcinoma.