TP53 and familial pancreatic carcinoma: GLI translocation to the nucleus has been reported to promote cell cycle progression [43], and inhibition of GLI by GANT61 was shown to induce a G1 arrest in 22Rv1—but not in PC3 and DU145 pancreatic cancer cells, concomitant with radiosensitization only in p53 wildtype 22Rv1 cells [35].