Although IVF complication rates are low, concern about the risks of some nonphysiological treatment procedures and the effects on the internal environment, such as ovarian stimulation regimens, high estrogen levels, and ovarian hyperstimulation syndrome (OHSS), continues to increase.[4,5] Great efforts and innovations, such as the use of gonadotropin-releasing hormone-agonist (GnRH-a) instead of human chorionic gonadotropin (hCG) as the ovulatory trigger and the adoption of a freeze-all strategy, have been made to optimize the ovarian stimulation regimens and treatment strategies.[6,7]. This evidence concerns the gene GNRH1 and ovarian hyperstimulation syndrome.