CDCA8 and hepatocellular carcinoma: Loss of CDCA8 led to defective cell proliferation and early embryonic lethality.[24] Previous studies revealed that CDCA8 expression was related with poor prognosis of patients with gastric cancer,[25] lung cancer[26] and hepatocellular carcinoma.[27] Another study also showed that CDCA8 was overexpressed in colorectal cancers, and that loss of CDCA8 suppressed the growth of cancer cells and induced apoptosis.[12]