The presence of SFPQ in the cytoplasm of HRV16-infected HeLa cells at 6 hours post-infection, the time at which RNA replication commences (Fig 7G), together with persistence of the cleavage fragment until at least 10 hours post-infection, would be highly compatible with a role for SFPQ in HRV16 RNA replication. The gene discussed is SFPQ; the disease is infection.