Another example is that aberrant expression level of hsa-mir-16 (3rd in the prediction list) could suppress cell apoptosis while promote growth by regulating the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and the ex-determining region Y-related high-mobility-group box transcription factor 6 (SOX6) which play important roles in the pathogenesis of ESCC [76]. The gene discussed is RECK; the disease is esophageal squamous cell carcinoma.