The previous study showed GATA4 and tyrosine kinase receptor ERBB2 formed a negative feedback regulatory loop in breast cancer cells [24], in our study, gene expression analyses of pancreatic cancer cell transfection with GATA4 gene had identified several sets of coregulated genes harbored in the progression of pancreatic cancer accounting for DNA replication, cell cycle and apoptosis[25]. Here, GATA4 is linked to pancreatic neoplasm.