The regulated genes were mainly enriched in the neuroactive ligand-receptor interaction, olfactory transduction, MAPK signaling pathway, calcium signaling pathway, glutamatergic synapse, JAK-STAT signaling pathway, osteoclast differentiation, dilated cardiomyopathy, bile secretion, taste transduction, primary immunodeficiency, and histidine metabolism (Fig 4, Table 4). The gene discussed is SOAT1; the disease is inborn error of immunity.