KCTD11 was reported to suppress the Hedgehog signaling pathway in medulloblastoma [2], and crosstalk between the Hedgehog and PI3K/AKT/mTORC1 pathways via Gli1 activation has been reported to occur in several types of cancer models including medulloblastoma, prostate cancer and breast cancer cell lines [77]. The gene discussed is GLI1; the disease is cancer.