In addition, mouse Kctd11 was identified as a tumor suppressor gene near TP53 in an in vivo mouse screen [16], and human KCTD11 deficiency is suggested to contribute to several cancers including medulloblastoma [2], hepatocellular carcinoma [17], and prostate adenocarcinoma [18]. This evidence concerns the gene KCTD11 and hepatocellular carcinoma.