REN and neoplasm: Among the 25 human KCTD family members [52], several have been linked to human cancers, including KCTD8 [53], KCTD12 [54], TNFAIP1 [3] and most notably KCTD11/Ren/KCASH1, a reported tumor suppressor in medulloblastoma, possibly by suppressing Hedgehog signaling [2, 55].