In said Yeh et al’s study, BITC-induced apoptosis was meditated by the reduction of Mcl-1 and Bcl-2 protein levels, disruption of mitochondria membrane potential (ΔΨm), and an increase of ROS production and PARP cleavage level in oral cancer OC2 cells [62]. This evidence concerns the gene MCL1 and lip and oral cavity carcinoma.