PTH and chronic kidney disease: The safety and efficacy of cinacalcet in adults with CKD and SHPT receiving dialysis has been extensively investigated [22–25], and its use, along with calcitriol, or vitamin D analogs, or a combination thereof, is included in the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines for PTH lowering in adult subjects with stage 5 CKD receiving dialysis [1].