Claudin-2 was detected only in duct cells of the normal pancreas [36]; claudin-2 was also detected in acinar cells in a porcine model of AP, but claudin-3, -4, -5, or -7 immunoreactivity in acinar and duct cells did not differ before and after induction of AP [38]. This evidence concerns the gene CLDN2 and alkaline phosphatase measurement.