IL18 and autoimmune thrombocytopenic purpura: To determine the susceptibility and clinical significance of the NLRP3 inflammasome in ITP, we examined the SNPs of three NLRP3 inflammasome components and two inflammatory cytokines, including NLRP3 (rs35829419), CARD8 (rs2043211), NF-κB-94ins/del ATTG, IL-18 (rs1946518), and IL-1β (rs16944).