In CVS, Ang-II is involved in several functions such as: (i) potent vasoconstriction (ii) elevation of blood pressure (iii) increase in vascular smooth muscle cell (VSMC) proliferation and hyperplasia in the aorta (iv) participation in the process of oxidants formation resulting in vascular damage, and accumulation of extracellular matrix metalloproteinases (MMP), and (v) aortic aneurysm and dissection (8, 52–55). This evidence concerns the gene AGT and aortic aneurysm.