No effect of vasculature SOD3 on hypertension caused by Ang-II (1) Increase vascular O2-· production (2) No further increase in O2-· production by Ang-II infusion (3) Modest reduction in endothelium-dependent vasorelaxation in Ang-II treatment (4) Marked reduction in NO bioavailability No further reduction in NO bioavailability by Ang-II infusion (5) No effect on basal blood pressure to Ang-II; in SOD3 VSMC deletion (6) Hypertensive response to Ang-II; in SOD3 CNS deletion. Here, SOD3 is linked to hypertensive disorder.