Lack of eNOS activity was associated with increase in the area of atherosclerotic lesions, and lead to the development of other vascular complications (1) Increase L-E interaction (2) Increase the expression of VCAM-1 by endothelial cells and smooth muscle cells (3) Increase mononuclear infiltration into the plaque lesion (4) Decrease NO level (5) Decrease superoxide production (6) Development of vascular complications including aortic aneurysm and aortic dissection (7) Development of distal coronary arteriosclerosis and perivascular and endomyocardial fibrosis. The gene discussed is VCAM1; the disease is aortic aneurysm.