Involvement of NOX1 in Ang-II-induced aortic dissection (1) Significant reduction in the number of mice who had sudden death compared to the wild-type (2) Blood pressure elevation similar in both the presence and absence of NOX1 in a norepinephrine treatment (3) No aortic dissection in norepinephrine-treated mice (4) Massive increase in TIMP1 gene expression compared to Ang-II-induced wild-type. Here, AGT is linked to Aortic dissection.