Pivotal role of NADPH oxidase and p47phoxin Ang-II-mediated hypertension (1) No increase in vascular O2-· production after Ang-II treatment (2) Blunted increase in blood pressure response to Ang-II (3) Loss of p47phox expression in aortic endothelium (4) Similar expression of TA1 receptor in p47phox−/− and wild-type. Here, FMO5 is linked to hypertensive disorder.