Production of RANKL activated by T-cells directly controls osteoclastogenesis, bone remodeling, and also associated with autoimmune diseases, cancers, leukemias, asthma, chronic viral infections, and periodontal disease (63). In particular, RANKL is more likely to be the pathogenetic principle that results in the destruction of bone and cartilage in arthritis. Here, TNFSF11 is linked to arthritic joint disease.