The activities of MCAD and ACSL were significantly decreased in the HF group compared to the control group (P<0.05), which was further deteriorated by Ara A (P<0.05) and significantly improved by Gs-Rb1, Aicar, and Aicar+Gs-Rb1 (P<0.05) without synergistic effects between Gs-Rb1 and Aicar (P>0.05). Here, ATIC is linked to hydrops fetalis.