The concentration of malonyl-CoA was significantly declined in the HF group compared to the control group (P=0.000), which was further deteriorated by Ara A (P=0.000) and significantly improved by Gs-Rb1 (P=0.006), Aicar (P=0.030), and Aicar+Gs-Rb1 (P=0.003), however, there existed no synergistic effect between Gs-Rb1 and Aicar (P>0.05). Here, RB1 is linked to hydrops fetalis.