Also, results of meta-analysis for association of LPL-PvuII with stroke risk revealed that there is significant decreased risk in the four following models: P-vs. P+ (OR= 0.72, 95%CI= 0.58-0.91, P= 0.005), P-P-vs. P+P+ (OR= 0.50 95%CI= 0.31-0.82, P= 0.006), P+P-+P-P-vs. P+P+ (OR= 0.72, 95% CI= 0.53-0.96, P= 0.027), P-P-vs. P+P++P+P- (OR= 0.581, 95%CI= 0.369-0.916, P= 0.019). The gene discussed is LPL; the disease is Stroke.