In addition, these results indicate that a reduction in p65/ERK complexes is linked to anti-apoptosis due to N-cadherin overexpression in HNSCC cells (Figure 7) and molecular targeting of MAPK/ERK activation to suppress NF-kB activity holds promise as an effective approach to re-sensitize resistant tumor cells. This evidence concerns the gene CDH2 and head and neck squamous cell carcinoma.