To further clarify the role of N-cadherin in cancer cell growth, we first examined whether there is a correlation between expression of several DRs, such as Fas, TNFR-1, TNFR-2, DR-5, DcR-2, and N-cadherin expression in six cell lines (HSC2, HOC313, KOSCC33A, Ho1N1, HOC719PE, and HOC719NE). This evidence concerns the gene TNFRSF1B and cancer.