Based on co-expression analysis in the TCGA CRC database, COX7A1 was highly co-expressed with LGALS1 coding for galectin-1 (LGALS1/galectin-1), a lectin that is upregulated in the tumor stroma and can inhibit immune response through CD45 protein phosphatase activity (Spearman’s correlation = 0.84). The gene discussed is LGALS1; the disease is neoplasm.