AGR2 and neoplasm: AGR2 was expressed in most (14/17 (82%)) metastatic lesions and, although the proportion of cells expressing AGR2 protein, regardless the intensity, was significantly higher in metastatic lesions compared with the matched primary tumour cells (data not shown), the quick-scores (which collated immunostaining intensity and proportion of positive cells) were not significantly different between the 2 groups (Figure 4).