Ex vivo analysis confirmed the increased accumulation of IntegriSense750 probe in the small intestine of tumor-bearing APC+/min mice compared to WT mice (Figure 2C and 2D): of note, several spots of probe accumulation can be identified in the small intestine of APC+/min mice (Figure 2C, white arrows), likely corresponding to the localization of the developed multiple small adenomas. This evidence concerns the gene APC and neoplasm.