We found that the commercially available probe IntegriSense (Perkin Elmer) [21] specifically accumulates in cancer tissues compared to healthy mucosa, allowing tumor visualization and the monitoring of neoplastic progression in a genetically-induced mouse model of the small intestine tumor (APC+/min) as well as in a chemically-induced model of colon cancer (DSS-treated APC+/min mice). Here, APC is linked to malignant colon neoplasm.