APC and neoplasm: To evaluate whether the expression of the integrin αvβ3 could be used to detect small intestine tumor formation in vivo, 24 h before the imaging, 18 weeks-old APC+/min mice and age-related WT mice were shaved and injected IV with 0.08 nmol/g of body weight of IntegriSense750 (Perkin Elmer), a commercial available probe specifically recognizing integrin αvβ3 [21] and emitting a near infrared (NIR) fluorescent signal at 750 nm wavelength.