To induce the formation of colorectal tumors, APC+/min and WT mice were administered with dextran sulfate sodium (DSS) in drinking water: DSS is a widely used irritant of the colonic mucosa, able to cause intestinal inflammation (in a B- and T-cell independent manner), likely through the damaging of epithelial monolayer lining the large intestine and the consequent dissemination of pro-inflammatory luminal content into the tissue [23]. This evidence concerns the gene APC and colorectal neoplasm.