NLRP3 and metabolic dysfunction-associated steatohepatitis: Since NLRP3 inflammasome has been reported to not only activate the inflammatory response but also possess noncanonical or noninflammatory action that may contribute to the progression of some chronic degenerative or fibrotic diseases [4–7], it is possible that the activation of NLRP3 inflammasome mediates NASH development via the “two-hit” mechanism.