Here, we found that MSC_IGF-1 had a clear effect in the regeneration of the skeletal muscle from mice chronically infected with T. cruzi, in which the loss of skeletal myofibers could be the result of direct damage induced by T. cruzi infection associated with sarcopenia induced by chronic inflammation and increased local and circulating levels of TNF-α [22]. Here, IGF1 is linked to sarcopenia.