The latest and largest study, a meta-analysis of 6,365 French and North-American CF patients, identified five regions outside the SLC26A9 locus that displayed significant association with variation in lung disease: the locus of the mucin genes MUC4 and MUC20, of the solute carrier genes SLC9A3 and SLC6A14, and of the HLA Class II region (Corvol et al., 2015). Here, SLC6A14 is linked to cystic fibrosis.