Moreover, SLC26A9 variants have been previously shown in genome wide association studies (GWAS) to contribute to the phenotype variability of meconium ileus (Sun et al., 2012) (rs7512462, rs4077468, rs4077469, rs7419153, rs12047830, rs12741299) and CF-related diabetes (CFRD, rs4077468, rs4077469, rs1874361) (Blackman et al., 2013). This evidence concerns the gene SLC26A9 and intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.