The use of quantitative neuroimaging methods (e.g., 18FDG-PET, POCE, 1H-MRS, MRA, and ASL) would be vital in future use to identify the efficacy of mTOR-related interventions and treatments for protecting brain functions in aging and various AD-related neurodegeneration, including vascular dementia and Down syndrome (Lin et al., 2016). This evidence concerns the gene MTOR and Alzheimer disease.