AKT1 and amyotrophic lateral sclerosis: Transplantation of hiPSC-derived glia-rich progenitors, which then gave rise to astrocytes, into the lumbar spinal cord of ALS mice improved the motor function and prolonged the lifespan of mice via activation of AKT signals (Kondo et al., 2014), exemplifying the rationale of cell therapy for ALS using hiPSC-derived glial cells.