Although our study revealed Dyrk1A presence in the hippocampal postsynaptic fraction and previous studies showed DYRK1A overexpression in DS, our data suggest that Dyrk1a-mediated phosphorylation GluN2A(pS1048) might contribute to DS synaptic alterations, a hypothesis that might be explored in the future. The gene discussed is DYRK1A; the disease is Dravet syndrome.