For metastatic colorectal cancer (mCRC), the confirmation of awild-type KRAS and NRAS gene is required before anti-EGFR monoclonal antibody therapies.4–7 In the context of non-small-cell lung cancer (NSCLC), treatment withEGFR tyrosine kinase inhibitors requires the presence of an activating variant inthe EGFR gene. This evidence concerns the gene EGFR and metastatic colorectal cancer.