We performed RING1B chromatin immunoprecipitation followed by massive parallel sequencing (ChIP-seq) of two breast cancer cell lines—estrogen receptor positive (ER+) luminal A cell line, T47D, and triple-negative breast cancer (TNBC) cell line, MDA-MB-231—and a non-tumorigenic transformed mammary epithelial cell line, MCF10A. Here, RNF2 is linked to breast cancer.