KEGG pathways showed that the cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, PPAR signaling pathway, PI3K-Akt signaling pathway, cell adhesion molecules (CAMs), regulation of lipolysis in adipocytes, malaria, platelet activation, HTLV-I infection, NK cell mediated cytotoxicity, Osteoclast differentiation, and Focal adhesion were highly associated with the DE mRNAs. The gene discussed is AKT1; the disease is malaria.