Given the link between PTPN22R620W and autoantibody associated autoimmune diseases, and the regulation of FcRs by Src and Syk family kinases, we set out to investigate if PTPN22 regulates FcγR dependent immune complex uptake and activation in DCs and whether this can alter T cell effector responses. The gene discussed is FCGR2A; the disease is autoimmune disease.