SFN and early-onset autosomal dominant Alzheimer disease: In addition to Abc transporters, SFN also upregulated Slc40a1 (also known as Ferroportin 1; a well-studied iron importer) which plays a critical role in cerebral iron homeostasis and has been implicated with several neurological disorders including Alzheimer’s disease brain pathology58–60, abnormal forebrain patterning and neural tube closure and inflammation61,62.