In addition to Abc transporters, SFN also upregulated Slc40a1 (also known as Ferroportin 1; a well-studied iron importer) which plays a critical role in cerebral iron homeostasis and has been implicated with several neurological disorders including Alzheimer’s disease brain pathology58–60, abnormal forebrain patterning and neural tube closure and inflammation61,62. The gene discussed is SLC40A1; the disease is early-onset autosomal dominant Alzheimer disease.