CHMP4B and infection: It was reported that infection of cells with Epstein–Barr virus (EBV), another herpesvirus, recruited CHMP4B to the NM, as observed in HSV-1-infected cells, and induced vacuole-like structures containing INM-associated proteins in the cytoplasm, unlike HSV-1 infection, and that ESCRT-III was required for the formation of these cytoplasmic structures46,47.